If you are searching for evidence to help answer a clinical question, PubMed has an interfaces specifically to help with this. PubMed's Clinical Queries search includes built-in filters to find research for different question types (Therapy, Clinical Prediction, Diagnosis, Etiology, and Prognosis). This allows for a quick but focused search strategy.
The 5-minute video below will walk you through the basics of using Clinical Queries to find clinically-relevant research.